Not personally, but a friend has had this happen. I don't think it's really a big deal. Companies needs change, and someone who may not have been right for them 2 years ago may be just what they need now. Given the long time span, I don't think there's anything to worry about. Now, if you were to get 2 interviews withing days of each other, and dress up with a mustache and funny glasses for the second one...
